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Treatment Options for Childhood Soft Tissue Sarcoma

For information about the treatments listed below, see the Treatment Option Overview section.

Newly Diagnosed Childhood Soft Tissue Sarcoma

Fat Tissue Tumors

Liposarcoma

Treatment of liposarcoma may include the following:

Bone and Cartilage Tumors

Extraskeletal mesenchymal chondrosarcoma

Treatment of extraskeletal mesenchymal chondrosarcoma may include the following:

Extraskeletal osteosarcoma

Treatment of extraskeletal osteosarcoma may include the following:

See the PDQ summary on Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment for more information.

Fibrous (Connective) Tissue Tumors

Desmoid-type fibromatosis

Treatment of desmoid-type fibromatosis may include the following:

Treatment of desmoid-type fibromatosis that has come back may include the following:

  • Observation and possibly surgery at a later time.
  • Chemotherapy.
Dermatofibrosarcoma protuberans

Treatment of dermatofibrosarcoma protuberans may include the following:

Fibrosarcoma
Infantile fibrosarcoma

Treatment of infantile fibrosarcoma may include the following:

Adult-type fibrosarcoma

Treatment of adult-type fibrosarcoma may include the following:

Inflammatory myofibroblastic tumor

Treatment of inflammatory myofibroblastic tumor may include the following:

Low-grade fibromyxoid sarcoma

Treatment of low-grade fibromyxoid sarcoma may include the following:

Myxofibrosarcoma

Treatment of myxofibrosarcoma may include the following:

Sclerosing epithelioid fibrosarcoma

Treatment of sclerosing epithelioid fibrosarcoma may include the following:

Skeletal Muscle Tumors

Rhabdomyosarcoma

See the PDQ summary on Childhood Rhabdomyosarcoma Treatment.

Smooth Muscle Tumors

Leiomyosarcoma

Treatment of leiomyosarcoma may include the following:

So-called Fibrohistiocytic Tumors

Plexiform fibrohistiocytic tumor

Treatment of plexiform fibrohistiocytic tumor may include the following:

Peripheral Nervous System Tumors

Ectomesenchymoma

Treatment of ectomesenchymoma may include the following:

Malignant peripheral nerve sheath tumor

Treatment of malignant peripheral nerve sheath tumor may include the following:

It is not clear whether giving radiation therapy or chemotherapy after surgery improves the tumor's response to treatment.

Malignant triton tumor

Malignant triton tumors may be treated the same as rhabdomyosarcomas and include surgery, chemotherapy, or radiation therapy. A regimen of targeted therapy, radiation therapy, and surgery with or without chemotherapy is being studied.

Pericytic (Perivascular) Tumors

Infantile hemangiopericytoma

Treatment of infantile hemangiopericytoma may include the following:

Infantile myofibromatosis

Treatment of infantile myofibromatosis may include the following:

Tumors of Unknown Origin (the place where the tumor first formed is not known)

Alveolar soft part sarcoma

Treatment of alveolar soft part sarcoma may include the following:

Clear cell sarcoma of soft tissue

Treatment of clear cell sarcoma of soft tissue may include the following:

Desmoplastic small round cell tumor

There is no standard treatment for desmoplastic small round cell tumor. Treatment may include the following:

Epithelioid sarcoma

Treatment of epithelioid sarcoma may include the following:

Extrarenal (extracranial) rhabdoid tumor

Treatment of extrarenal (extracranial) rhabdoid tumor may include the following:

Extraskeletal myxoid chondrosarcoma

Treatment of extraskeletal myxoid chondrosarcoma may include the following:

Perivascular epithelioid cell tumors (PEComas)

Treatment of perivascular epithelioid cell tumors may include the following:

Primitive neuroectodermal tumor (PNET)/extraskeletal Ewing tumor

See the PDQ summary on Ewing Sarcoma Treatment.

Synovial sarcoma

Treatment of synovial sarcoma may include the following:

Undifferentiated/unclassified sarcoma

These tumors include undifferentiated pleomorphic sarcoma /malignant fibrous histiocytoma (high-grade). There is no standard treatment for these tumors. Treatment may include the following:

See the PDQ summary on Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment for information about the treatment of malignant fibrous histiocytoma of bone.

Blood Vessel Tumors

Angiosarcoma of soft tissue

Treatment of angiosarcoma may include the following:

Epithelioid hemangioendothelioma

Treatment of epithelioid hemangioendothelioma may include the following:

Metastatic Childhood Soft Tissue Sarcoma

Treatment of childhood soft tissue sarcoma that has spread to other parts of the body at diagnosis may include the following:

For treatment of specific tumor types, see the Treatment Options for Childhood Soft Tissue Sarcoma section.

Check the list of NCI-supported cancer clinical trials that are now accepting patients with nonmetastatic childhood soft tissue sarcoma and metastatic childhood soft tissue sarcoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI website.

Recurrent and Progressive Childhood Soft Tissue Sarcoma

Treatment of recurrent or progressive childhood soft tissue sarcoma may include the following:

Check the list of NCI-supported cancer clinical trials that are now accepting patients with recurrent childhood soft tissue sarcoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI website.


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